Which of the following vaccines provides protection against Strep pneumoniae?

The vaccine that provides protection against Streptococcus pneumoniae is PCV13, which stands for Pneumococcal Conjugate Vaccine 13-valent. This vaccine is specifically designed to protect against infections caused by pneumococcal bacteria, which can lead to serious illnesses such as pneumonia, meningitis, and sepsis. The "13" in PCV13 refers to the 13 different serotypes of S. pneumoniae that the vaccine targets, which together account for a significant proportion of pneumococcal disease incidence.

The other vaccines listed do not offer protection against S. pneumoniae. TDAP (tetanus, diphtheria, and pertussis) targets different pathogens entirely and has no impact on pneumococcal infections. MMR (measles, mumps, and rubella) is focused on viral diseases and does not provide any immunity to bacterial infections such as those caused by S. pneumoniae. Finally, the influenza vaccine protects specifically against different strains of the influenza virus, with no relevance to pneumococcal bacteria. Therefore, PCV13 is specifically formulated to prevent illness caused by Streptococcus pneumoniae, making it the correct choice.